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KMID : 0616120170480020166
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Korean Journal of Pharmacognosy
2017 Volume.48 No. 2 p.166 ~ p.171
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Antifungal Effect of Sanguisorba officinalis L. fractions on Candida albicans
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Lee Jae-Hyeok
Choi Bong-Sil
Park Jeong-Sook
Shin Tae-Yong
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Abstract
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We have studied the antifungal effect of 19 medicinal plants with paper disc diffusion method against candida albicans. As a result, Sanguisorba officinalis L., Cinnamomum cassia, Rheum coreanum, Perilla frutescens and Eugenia caryophyllata have been found to be effective against C. albicans. Among these, Sanguisorba officinalis L. was most effective at 24 hours and 48 hours. Its clear zone diameter was 17 mm for 24 hours and 16 mm for 48 hours. The antifungal activity of the solvent fraction of Sanguisorba officinalis L. by n-hexane, chloroform, ethyl acetate and n-butanol was the best for the chloroform fraction of 28 mm for 24 hours and 18 mm for 48 hours. The MIC concentration of the chloroform fraction was 80 μg/50 μl at 24 hours and 240 μg/50 μl at 48 hours.
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KEYWORD
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Sanguisorba officinalis L., Candida albicans, Antifungal effect, Chloroform fraction
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